Dr. Bear is an internationally recognized expert on how experience modifies synaptic communication between neurons in the brain. Discoveries in his lab led to the key insight that multiple aspects of Fragile X Syndrome could arise from excessive activation of a biochemical pathway downstream of metabotropic glutamate receptor 5. Based upon these insights, Seaside Therapeutics licensed a novel series of compounds targeting this receptor. Dr. Bear continues to closely advise the Company. Prior to joining the Picower Institute, Dr. Bear was the Sidney A. and Dorothea Doctors Fox Professor of Neuroscience at Brown University. He was a founder of Sention and served as Chair of Sention's Scientific Advisory Board from 1999 to 2005. Among numerous honors, Bear received the Society for Neuroscience Young Investigator Award in 1993, has been an Investigator of the Howard Hughes Medical Institute since 1994, was elected as a Fellow of the American Academy of Arts and Sciences in 2004 and received the William Rosen Research Award from the National Fragile X Foundation in 2006. Dr. Bear received his PhD from Brown University and was a Fellow at the Max-Planck-Institut fur Hirnforschung, Frankfur
Dr. Warren is world-renowned for his research on the genetics of mental retardation and led the international team that identified the FMR1 (Fragile X mental retardation 1) gene, which is responsible for Fragile X Syndrome. Dr. Warren is President of the American Society of Human Genetics and was Editor-in-Chief of The American Journal of Human Genetics from 1999 to 2005. Among his awards are the William Rosen Research Award from the National Fragile X Foundation, a MERIT award from the National Institute of Health and the William Allan Award from the American Society of Human Genetics. In 2003, he was inducted into the National Institute of Child Health and Human Development's Hall of Honor and, in 2004, Dr. Warren was elected to the Institute of Medicine of the National Academies. Dr. Stephen T. Warren received his PhD in human genetics from Michigan State University.